- Southern Cigar Co.
- Southern Fried Cotton
- Southern Tide
- Southern Scholar
- Sourcemore
- Soviet Power
- Soxiety
- SoYoung
- Spa Gregorie's
- Space Needle
- SpaceCraft
- SPAM Shop
- SpaRoom
- Sparktec Motorsports
- Speakman
- Spectra Baby USA
- Spectrum Antenna
- Speed Raceway
- Speech Buddies
- Spent
- Spherion
- Spektrum glasses
- Spencer Barnes
- Sphero
- Spicin Foods
- Spiceworks
- Spidertrax
- SpiderVPN
- Spicy Subscriptions
- SpiderWebShade
- Spin Master
- Spiffster Club
- Spinnup
- Spira Footwear
- Spirit Jersey
- Splash Car Wash
- Splash Lagoon
- Splashtop
- Splendies
- Splice
- Splish Splash
- SpoofTel
- Spongelle
- Spoon Sleep
- Spoolies Hair Curlers
- Spoonflower
- Sports Illustrated
- Spring Step Shoes
- Springboard
- Sprinkles Cupcakes
- Sproutfit
- Squeaker Sneakers
- Squirrels
- Squijoo
- SRA Soldering Products
- SSL
- St. Croix Saddlery
- Stackers
- Stag Arms
- Stagecoach Festival
- Stampin' Up
- Stamp-n-Storage
- Standard Cocoa
- Star Furniture
- Star Shop
- Star Wars Authentics
- Starfish Project
- Startek Enterprises
- StartingAClothingLine
- Static Nails
- Steak Escape Sandwich Grill
- Steal One
- Steelcase
- Steinberg
- Steep Discount Mart
- Stella Bella
- STEM Discovery Boxes
- Stemology
- Steps To Literacy
- Stephen Joseph